Receptor recognition and cross-species infections of SARS coronavirus
Identifieur interne : 001F23 ( Main/Exploration ); précédent : 001F22; suivant : 001F24Receptor recognition and cross-species infections of SARS coronavirus
Auteurs : Fang LiSource :
- Antiviral Research [ 0166-3542 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Glycoprotéine de spicule des coronavirus (), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (métabolisme), Humains, Infection croisée (génétique), Infection croisée (métabolisme), Infection croisée (virologie), Peptidyl-Dipeptidase A (génétique), Peptidyl-Dipeptidase A (métabolisme), Récepteurs viraux (génétique), Récepteurs viraux (métabolisme), Spécificité d'espèce, Syndrome respiratoire aigu sévère (métabolisme), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (métabolisme).
- MESH :
- génétique : Glycoprotéine de spicule des coronavirus, Infection croisée, Peptidyl-Dipeptidase A, Récepteurs viraux, Virus du SRAS.
- métabolisme : Glycoprotéine de spicule des coronavirus, Infection croisée, Peptidyl-Dipeptidase A, Récepteurs viraux, Syndrome respiratoire aigu sévère, Virus du SRAS.
- virologie : Infection croisée, Syndrome respiratoire aigu sévère.
- Animaux, Glycoprotéine de spicule des coronavirus, Humains, Spécificité d'espèce, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Cross Infection (genetics), Cross Infection (metabolism), Cross Infection (virology), Humans, Peptidyl-Dipeptidase A (genetics), Peptidyl-Dipeptidase A (metabolism), Receptors, Virus (genetics), Receptors, Virus (metabolism), SARS Virus (chemistry), SARS Virus (classification), SARS Virus (genetics), SARS Virus (metabolism), Severe Acute Respiratory Syndrome (metabolism), Severe Acute Respiratory Syndrome (virology), Species Specificity, Spike Glycoprotein, Coronavirus (chemistry), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (metabolism).
- MESH :
- chemical , chemistry : Spike Glycoprotein, Coronavirus.
- chemical , genetics : Peptidyl-Dipeptidase A, Receptors, Virus, Spike Glycoprotein, Coronavirus.
- chemistry : SARS Virus.
- classification : SARS Virus.
- genetics : Cross Infection, SARS Virus.
- metabolism : Cross Infection, Peptidyl-Dipeptidase A, Receptors, Virus, SARS Virus, Severe Acute Respiratory Syndrome, Spike Glycoprotein, Coronavirus.
- virology : Cross Infection, Severe Acute Respiratory Syndrome.
- Animals, Humans, Species Specificity.
Abstract
SARS-CoV recognizes host receptor ACE2 via its receptor-binding domain (RBD). Residue differences in host ACE2 present species barriers for SARS-CoV infections. SARS-CoV can adapt to ACE2 from several species through RBD mutations. Structural studies have revealed receptor adaptation mechanisms of SARS-CoV. Structural studies also allow predictions of future SARS-CoV evolution.
Url:
DOI: 10.1016/j.antiviral.2013.08.014
PubMed: 23994189
PubMed Central: 3840050
Affiliations:
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Le document en format XML
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recognition and cross-species infections of SARS coronavirus</title><author><name sortKey="Li, Fang" sort="Li, Fang" uniqKey="Li F" first="Fang" last="Li">Fang Li</name></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cross Infection (genetics)</term><term>Cross Infection (metabolism)</term><term>Cross Infection (virology)</term><term>Humans</term><term>Peptidyl-Dipeptidase A (genetics)</term><term>Peptidyl-Dipeptidase A (metabolism)</term><term>Receptors, Virus (genetics)</term><term>Receptors, Virus (metabolism)</term><term>SARS Virus (chemistry)</term><term>SARS Virus (classification)</term><term>SARS Virus (genetics)</term><term>SARS Virus (metabolism)</term><term>Severe Acute Respiratory Syndrome (metabolism)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Species Specificity</term><term>Spike Glycoprotein, Coronavirus (chemistry)</term><term>Spike Glycoprotein, Coronavirus (genetics)</term><term>Spike Glycoprotein, Coronavirus (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Glycoprotéine de spicule des coronavirus ()</term><term>Glycoprotéine de spicule des coronavirus (génétique)</term><term>Glycoprotéine de spicule des coronavirus (métabolisme)</term><term>Humains</term><term>Infection croisée (génétique)</term><term>Infection croisée (métabolisme)</term><term>Infection croisée (virologie)</term><term>Peptidyl-Dipeptidase A (génétique)</term><term>Peptidyl-Dipeptidase A (métabolisme)</term><term>Récepteurs viraux (génétique)</term><term>Récepteurs viraux (métabolisme)</term><term>Spécificité d'espèce</term><term>Syndrome respiratoire aigu sévère (métabolisme)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS ()</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Peptidyl-Dipeptidase A</term><term>Receptors, Virus</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cross Infection</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine de spicule des coronavirus</term><term>Infection croisée</term><term>Peptidyl-Dipeptidase A</term><term>Récepteurs viraux</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cross Infection</term><term>Peptidyl-Dipeptidase A</term><term>Receptors, Virus</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glycoprotéine de spicule des coronavirus</term><term>Infection croisée</term><term>Peptidyl-Dipeptidase A</term><term>Récepteurs viraux</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infection croisée</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cross Infection</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Species Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Glycoprotéine de spicule des coronavirus</term><term>Humains</term><term>Spécificité d'espèce</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0095">SARS-CoV recognizes host receptor ACE2 via its receptor-binding domain (RBD).</p></list-item><list-item id="o0010"><label>•</label><p id="p0100">Residue differences in host ACE2 present species barriers for SARS-CoV infections.</p></list-item><list-item id="o0015"><label>•</label><p id="p0105">SARS-CoV can adapt to ACE2 from several species through RBD mutations.</p></list-item><list-item id="o0020"><label>•</label><p id="p0110">Structural studies have revealed receptor adaptation mechanisms of SARS-CoV.</p></list-item><list-item id="o0025"><label>•</label><p id="p0115">Structural studies also allow predictions of future SARS-CoV evolution.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Annan, A" uniqKey="Annan A">A. 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